Not known Factual Statements About phenobarbital sodium drug class
Not known Factual Statements About phenobarbital sodium drug class
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pentobarbital will lower the extent or effect of lefamulin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Prevent or Use Alternate Drug. Steer clear of coadministration of lefamulin with strong or reasonable CYP3A inducers Except the reward outweighs threats. Monitor for reduced efficacy.
Intramuscular Administration: IM injection on the sodium salts of barbiturates ought to be manufactured deeply into a sizable muscle, along with a volume of 5 mL really should not be exceeded at any one web-site thanks to possible tissue irritation.
pentobarbital will lower the extent or effect of duvelisib by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Stay away from or Use Alternate Drug. Coadministration with a solid CYP3A inducer decreases duvelisib area under the curve (AUC), which can reduce duvelisib efficacy.
Contraindicated (1)pentobarbital will decrease the extent or effect of roflumilast by influencing hepatic/intestinal enzyme CYP3A4 metabolism.
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pentobarbital will lessen the level or effect of cariprazine by affecting hepatic/intestinal enzyme CYP3A4 metabolism.
pentobarbital improves toxicity of ifosfamide by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Observe. CYP3A4 inducers could increase the metabolism of ifosfamide to its Lively alkylating metabolites.
pentobarbital will reduce the level or effect of nelfinavir by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Keep track of.
pentobarbital will decrease the extent or effect of nitrendipine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Insignificant/Significance Mysterious.
pentobarbital and daridorexant equally boost sedation. Modify Therapy/Keep track of Closely. Coadministration improves hazard of CNS depression, which can result in additive impairment of psychomotor general performance and trigger daytime impairment.
pentobarbital will lower the level or effect of irinotecan liposomal by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Keep track of.
pentobarbital will minimize the extent or effect of bosentan by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Insignificant/Significance Not known.
pentobarbital will lessen the level or effect of tolterodine by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Keep an eye on.
Acute or chronic here discomfort: Warning really should be exercised when barbiturates are administered to sufferers with acute or Serious discomfort, simply because paradoxical pleasure might be induced or significant symptoms could possibly be masked.